Eshmuno^® S – for superior downstream mAb purification

For biopharmaceutical companies, efficiency and safety are two key requirements for sustainable success. In order to reduce costs, manufacturers are constantly striving to increase efficiency and productivity of their processes while at the same time securing maximal safety and purity of their pharmaceuticals. Downstream processing is not only the most time-consuming and costly process step in the manufacture of biological drugs, it is also crucial for the final drug’s purity. Therefore, particular care has to be taken when selecting the raw materials which come in direct contact with the biological active ingredient. With Eshmuno^® S, you achieve superior productivity and maximum performance in your downstream purification of monoclonal antibodies (mAb).

Eshmuno^® S: Outstanding performance

Eshmuno^® S is the first product of the newly introduced Eshmuno^® family of “SMART” ion-exchange resins. Eshmuno^® S is a strong cation exchanger and highly productive in direct capture and post-proteins A steps.

Like all Eshmuno^® products, Eshmuno^® S combines a tentacle structure for more effective binding of the target substances with the advantages of a new hydrophilic polyvinyl ether base matrix. Eshmuno^® S exhibits a superior binding capacity for antibodies compared to other modern cation-exchangers. Moreover, Eshmuno^® S allows the use of much higher flow rates while the biomolecule is still strongly bound by the tentacle.

Superior mAb binding capacity in direct capture step
Dynamic binding capacity (DBC) of Eshmuno® S for direct capture of monoclonal antibody mAb2 at 5% breakthrough and 5 minutes residence time from a real diluted feedstock.	Excellent pressure flow behaviour can be achieved with Eshmuno® S: 20 cm i.d. column; 19.5 cm bed heigh; 8% compression recorded in 150 mM NaCl

Efficient HCP removal with Eshmuno^® S

A crucial property of any ion exchange material in biochromatography is the ability to specifically select the target biomolecule. Eshmuno^® S features a high selectivity and wide flexibility for the specific purification challenge. With its innovative features, Eshmuno^® S is the most efficient ion-exchange resin available for removal of host cell proteins.

Eshmuno^® S: Save manufacturing costs

Thanks to the excellent pressure flow behaviour of Eshmuno^® S, you can achieve an outstanding productivity of more than 40 mg/ml x h in downstream processing. As a result, you can save considerable manufacturing costs in your mAb production.

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